PRA – Progressive Retinal Atrophy
Progressive Rod-Cone Degeneration (PRCD / PRA-prcd)
General
PRA has multiple variants which effect different breeds. Research to date shows that Cocker Spaniels are effected by the prcd variant, it is commonly abbreviated as PRCD or prcd-PRA.
Progressive rod-cone degeneration (PRCD) is an inherited form of late-onset progressive retinal atrophy (PRA) an inherited eye disease affecting English Cocker Spaniels. PRCD affects the photoreceptor cells in the eye involved in both night and day vision
The age of onset varies between individual Cocker Spaniels with PRCD. Evidence of retinal disease can first be seen on an Electroretinogram in dogs older than 2.5 years of age, but most affected dogs will not show signs of vision loss until 8 to 12 years of age or later.
PRA has several different forms, but progressive rod cone degeneration (PRCD) is the most widespread, and occurs in many other breeds.
In most forms of PRA, Symptoms often start with vision problems in dim light (night blindness) and loss of peripheral vision. The dog first becomes uncertain and fearful in the dark. This is due to the atrophy of retinal rod cells, which are important for night vision. Over time affected dogs continue to lose night vision and begin to show visual deficits in bright light. The dog becomes completely blind as the retinal cone cells atrophy. The pupil is wide and the increased reflection of the fundus can be seen especially clearly when the light is focused on the enlarged pupil.
Although there can be individual variation in the age of onset and the rate of disease progression, the disease eventually progresses to complete blindness in most dogs. There are other eye disorders that can appear clinically similar to PRCD. Genetic testing will confirm this.
There is no treatment for PRA or PRCD at this time. So its important that you purchase your cocker spaniel puppy from a reputable breeder undertaking DNA health testing.
DNA Testing is not done at your local vets.
My Research Notes on PRA-PRCD
My thoughts on developing minimum breed standard testing. As PRA can be scientifically determined using DNA, it should be required in any programme. There is no reason to undertake clinical evaluations for PRA . * See other Eye Conditions.
Reliable genetic testing for determining breeding strategies is important so the gene diversity is retained and a depressed gene pool does not create other problems within the breed
Cocker Spaniels that don't carry the mutation have no risk of having PRCD affected pups. And successful breeding strategies have breed clear to carrier/affected slowly reducing the incident of the disease.
Because symptoms do not appear until adulthood, genetic testing should be performed before breeding. At least one parent should be confirmed clear of the mutation in order to eliminate this from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended.
However, please remember because there are multiple types of PRA caused by mutations in other genes, a normal result in PRCD does not exclude the possibility of other types of PRA being identified in the future. Its important to keep learning.
Eye exams can detect the early clinical signs of different forms PRA, and cataracts which often develop concurrently.
Check Out The Progress Made In Reducing PRA-Prcd
PRA-Prcd Articles
PRA Around The World
The Global Frequency Analyses of Canine Progressive Rod-Cone Study shows that genetic testing informed breeding decisions to produce fewer affected dogs.
However, the presence of dogs homozygous for the disease variant, especially for prcd-pra, was still observed fourteen years after test availability, potentially due to crosses of unknown carriers.
The genetic testing has proven to be a invaluable tool and an intrinsic part of breeding healthy cockers and reducing the likelihood of disease.
informal data collected from RKC & CSDB
Other databases had insufficient validation of data to be included, and some of these dogs will be on the CSDB
Data lasted updated February 2024
% are more important when considering these statistics rather than the numbers recorded above, as some dogs results may have been duplicated in different databases